Hematology

Hematological disorders can be classified into malignant and nonmalignant blood disorders. Nonmalignant blood disorders include hemoglobinopathies such as thalassemia and sickle-cell anemia, other types of anemias, and coagulopathies such as hemophilia. Hemoglobinopathies are genetic diseases and, apart from α- and β-thalassemia, include diseases caused by abnormal hemoglobin structure, manifesting in mild to severe anemia and multi-organ problems. Clotting disorders with genetic causes also include hemophilia and Von Willebrand disease, both of which are caused by low levels of clotting factors in the blood.

Other nonmalignant disorders like anemia and pulmonary embolism could be caused by various factors, including diet and lifestyle. Idiopathic thrombocytopenic purpura is a hematological disease characterized by an abnormal drop in the blood platelet concentration, which then results in bruising, nosebleeds, bleeding gums, and internal bleeding since platelets are involved in clotting. While idiopathic thrombocytopenic purpura is not inherited or contagious, the cause is yet unknown. In most cases, idiopathic thrombocytopenic purpura occurs in children after a viral infection such as chicken pox.

Malignant blood disorders include leukemia, lymphomas, and myelomas and can affect people of all ages. Malignant hematological disorders could be caused by various factors, including genetics, lifestyle, and environment. Polycythemia vera is a form of leukemia known as a myeloproliferative neoplasm, characterized by excessive production of red blood cells in the bone marrow, which causes blood to become more viscous and increases the risks of clots and heart attack. Myelofibrosis is another myeloproliferative form of leukemia where the bone marrow produces an excess of stem cells resulting in inflammation and scar tissue formation in the bone marrow. Malignant lymphomas, including Hodgkin’s lymphoma, affect the lymphatic system and result in abnormal lymphocytes.

Myelodysplastic syndromes refer to a group of cancers where blood stem cells in the bone marrow fail to mature and form various mature blood cells. This results in refractory anemia, refractory cytopenia, chronic myelomonocytic leukemia, and various other cancers due to the insufficiency of red and white blood cells in the blood. Multiple myeloma is a form of cancer that results in excess plasma cells in the blood. The overcrowding of plasma cells in the blood causes a shortage of red blood cells, platelets, and white blood cells resulting in anemia, thrombocytopenia, and leukopenia, respectively. Multiple myeloma can also affect the osteoblasts and osteoclasts that keep bones healthy, causing bone degeneration and fractures.